Kashrut: Open, Uncooked Wine: From When May a Non-Observant Person Not Handle?

A non-Jew or non-shomer Shabbat Jew may not handle wine (or grape juice) once the juice has been separated from the lees (the remaining solid parts of the grapes).
Note Once ANY juice has been removed from the vat, all of the remaining grape juice or wine becomes subject to becoming non-kosher if contacted by anyone other than a shomer-Shabbat Jew.